Chaiyen Research Group

Dr.Chaiyen's lab team focuses on developing deep insights into enzymatic mechanisms, discovering new enzymatic functions and re-routing of metabolic networks. The team also includes technology and engineering specialists who focus on prototype development, scaling up and implementation for real life usage.

About us

Dr. Chaiyen’s research interests are in the broad areas of enzyme catalysis, enzyme engineering, systems biocatalysis, metabolic engineering and synthetic biology. Her group studies flavin-dependent, PLP-dependent, redox and aldolase enzymes. They have contributed significantly to the understanding of many fundamental aspects of these systems including mechanisms of oxygen activation by flavoenzymes, reduced flavin transfer between proteins, oxygenation and oxidation by flavin-dependent enzymes. In addition to developing deep insights into enzymatic mechanisms, they also focus on discovering of new enzymatic functions and re-routing of metabolic networks. With the mission to translate their scientific discoveries into real applications, her group has collaborations with several private sector entities and also founded their own startups, Enzmart Biotech, in 2016 and BioSynThai Biotech in 2020.

Technology

Our technology and startup

C-ROS

Cash Return from ZeroWaste and Segregation of Trash

Enzmart

The main goal is to translate our deep understanding of enzymatic reactions into applied technology.

BioSynThai

Our goal is to be one of the most prominent ventures in biotechnology academia.

BioVis

Plant booster for Safe and Sustainable Agriculture

Highlighted Findings

JACS Au
2024

Ancestral sequence reconstruction for designing biocatalysts and investigating their functional mechanisms

Biocatalysis has emerged as a green approach for efficient and sustainable production in various industries...

https://doi.org/10.1021/jacsau.4c00653

Frontpage coverage

RSC Chem Biol
2024 Jun

Enhancement of tryptophan 2-monooxygenase thermostability by semi-rational enzyme engineering: a strategic design to minimize experimental investigation

Tryptophan 2-monooxygenase (TMO) is an FAD-bound flavoenzyme which catalyzes the oxidative decarboxylation of L-tryptophan to produce indole-3-acetamide (IAM) and carbon dioxide...

https://doi.org/10.1039/d4cb00102h

Backpage coverage

Angew Chem
2024 Jun

On the Mechanisms of Hypohalous Acid Formation and Electrophilic Halogenation by Non-Native Halogenases

Electrophilic halogenases in nature are typically not efficient. Guided by flavin-dependent halogenase mechanisms and taking advantage of the versatile reactivity of a flavin hydroperoxide adduct and in situ generation of H2O2 by flavin-dependent enzymes...

https://doi.org/10.1002/anie.202403858