Dr. Chaiyen’s research interests are in the broad areas of enzyme catalysis, enzyme engineering, systems biocatalysis, metabolic engineering and synthetic biology. Her group studies flavin-dependent, PLP-dependent, redox and aldolase enzymes. They have contributed significantly to the understanding of many fundamental aspects of these systems including mechanisms of oxygen activation by flavoenzymes, reduced flavin transfer between proteins, oxygenation and oxidation by flavin-dependent enzymes. In addition to developing deep insights into enzymatic mechanisms, they also focus on discovering of new enzymatic functions and re-routing of metabolic networks. With the mission to translate their scientific discoveries into real applications, her group has collaborations with several private sector entities and also founded their own startups, Enzmart Biotech, in 2016 and BioSynThai Biotech in 2020.
The main goal is to translate our deep understanding of enzymatic reactions into applied technology.
Biocatalysis has emerged as a green approach for efficient and sustainable production in various industries...
https://doi.org/10.1021/jacsau.4c00653
Frontpage coverage
Tryptophan 2-monooxygenase (TMO) is an FAD-bound flavoenzyme which catalyzes the oxidative decarboxylation of L-tryptophan to produce indole-3-acetamide (IAM) and carbon dioxide...
https://doi.org/10.1039/d4cb00102h
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Electrophilic halogenases in nature are typically not efficient. Guided by flavin-dependent halogenase mechanisms and taking advantage of the versatile reactivity of a flavin hydroperoxide adduct and in situ generation of H2O2 by flavin-dependent enzymes...