Chaiyen Research Group

Dr.Chaiyen's lab team focuses on developing deep insights into enzymatic mechanisms, discovering new enzymatic functions and re-routing of metabolic networks. The team also includes technology and engineering specialists who focus on prototype development, scaling up and implementation for real life usage.

About us

Dr. Chaiyen’s research interests are in the broad areas of enzyme catalysis, enzyme engineering, systems biocatalysis, metabolic engineering and synthetic biology. Her group studies flavin-dependent, PLP-dependent, redox and aldolase enzymes. They have contributed significantly to the understanding of many fundamental aspects of these systems including mechanisms of oxygen activation by flavoenzymes, reduced flavin transfer between proteins, oxygenation and oxidation by flavin-dependent enzymes. Their research contributes to applications in circular economy, green chemistry, white biotechnology, biofuels, biorefinery, biosensors and bioimaging. With the mission to translate their scientific discoveries into real applications, her group has collaborations with several private sector entities and also founded their own startups, Enzmart Biotech, in 2016 and BioSynThai Biotech in 2020.

Technology

Our technology and startup

C-ROS

Cash Return from ZeroWaste and Segregation of Trash

Enzmart

The main goal is to translate our deep understanding of enzymatic reactions into applied technology.

BioSynThai

Our goal is to be one of the most prominent ventures in biotechnology academia.

BioVis

Plant booster for Safe and Sustainable Agriculture

Highlighted

Frontpage coverage

Chem Bio Chem
2020 July

A Minimized Chemoenzymatic Cascade for Bacterial Luciferase in Bioreporter Applications

The nicotinamide biomimetic BNAH has been demonstrated to serve as an effective reductant for generating reduced flavin in the chemoenzymatic cascade reaction of bacterial luciferase.

https://doi.org/10.1002/cbic.202000100

Angew Chem
2019 September

A Chemo‐Enzymatic Cascade for the Smart Detection of Nitro‐ and Halogenated Phenols

The flavin‐dependent monooxygenase, HadA, catalyzes the dehalogenation and denitration of the toxicants, nitro‐ and halogenated phenols, to benzoquinone.

https://doi.org/10.1002/anie.201904923

Chem Sci
2018 October

Oxidative dehalogenation and denitration by a flavin-dependent monooxygenase is controlled by substrate deprotonation

Enzymes that are capable of detoxifying halogenated phenols (HPs) and nitrophenols (NPs) are valuable for bioremediation and waste biorefining.

https://doi.org/10.1039/C8SC01482E