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Chem Bio Chem
2020 July

A Minimized Chemoenzymatic Cascade for Bacterial Luciferase in Bioreporter Applications

The nicotinamide biomimetic BNAH has been demonstrated to serve as an effective reductant for generating reduced flavin in the chemoenzymatic cascade reaction of bacterial luciferase.


Angew Chem
2019 September

A Chemo‐Enzymatic Cascade for the Smart Detection of Nitro‐ and Halogenated Phenols

The flavin‐dependent monooxygenase, HadA, catalyzes the dehalogenation and denitration of the toxicants, nitro‐ and halogenated phenols, to benzoquinone.


Chem Sci
2018 October

Oxidative dehalogenation and denitration by a flavin-dependent monooxygenase is controlled by substrate deprotonation

Enzymes that are capable of detoxifying halogenated phenols (HPs) and nitrophenols (NPs) are valuable for bioremediation and waste biorefining.


ACS Catalysis
2015 August

p-Hydroxyphenylacetate 3-Hydroxylase as a Biocatalyst for the Synthesis of Trihydroxyphenolic Acids

Trihydroxyphenolic acids such as 3,4,5-trihydroxycinnamic acid (3,4,5-THCA) 4c and 2-(3,4,5-trihydroxyphenyl)acetic acid (3,4,5-THPA) 2c are strong antioxidants that are potentially useful as medicinal agents.