Dr. Chaiyen’s research interests are in the broad areas of enzyme catalysis, enzyme engineering, systems biocatalysis, metabolic engineering and synthetic biology. Her group studies flavin-dependent, PLP-dependent, redox and aldolase enzymes. They have contributed significantly to the understanding of many fundamental aspects of these systems including mechanisms of oxygen activation by flavoenzymes, reduced flavin transfer between proteins, oxygenation and oxidation by flavin-dependent enzymes. Their research contributes to applications in circular economy, green chemistry, white biotechnology, biofuels, biorefinery, biosensors and bioimaging. With the mission to translate their scientific discoveries into real applications, her group has collaborations with several private sector entities and also founded their own startups, Enzmart Biotech, in 2016 and BioSynThai Biotech in 2020.
Dr. Chaiyen’s lab team focuses on developing deep insights into enzymatic mechanisms, discovering new enzymatic functions and re-routing of metabolic networks. The team also includes technology and engineering specialists who focus on prototype development, scaling up and implementation for real life usage. Both parts of the team work together and collaborate with various government, private and community sector entities to deliver innovative solutions for sustainability issues such as waste management, climate change, sustainable agriculture and food safety
Dr. Chaiyen’s group also collaborate closely with Dr. Thanyaporn Wongnate (VISTEC) on anaerobic digestion and Dr. Nopphon Weeranopphanant (Burapha U) on process engineering. Other scientific collaborations include those with colleagues in Thailand including Dr Ubolsree Leartsakulpanich (NSTDA), Dr. Penchit Chitnumsub (NSTDA), Assoc. Dr. Jeerus Sucharitakul (Chulalongkorn U), Assist. Dr. Assist. Dr. Ruchanok Tinikul (Mahidol U), Somchart Maenpuen (Burapha U) etc as well as leading researchers around the world.